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Some haciendas in Yucatán have been renovated into beautiful five star hotels, complete with elegant rooms, sumptuous dining facilities, swimming pools and magnificent grounds. These have inspired modern Yucatán architecture and interior design.

Other haciendas are museums, providing a glimpse into former colonial times. Others are lived in by locals whose ancestors reclaimed them during the Mexican Revolution. And still others remain unrestored and open to the ravages of time.

Following is a list of some of the haciendas in our region, with services ranging from tours to gourmet dining to spas to deluxe accommodation (both hotel and private rental). All are available for private special events like weddings, etc.

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. A stately hacienda, nestled in lush gardens, this hotel has modern amenities that include color satellite TV, AC, an excellent location, restaurant, and pool. Hacienda Chichén also offers YaxkinSpa, a Maya retreat designed for sanctuary, healing and renewal. Check the website for rates and services. 
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Hacienda Chichén Resort

Luxury Collection In the early 1990’s we find visionary Mexican banker Roberto Hernandez coming to the Yucatán and buying some of the derelict haciendas and turning them into Grand Tourism hotels after carefully, lovingly and faithfully restoring them (under the talented hand of Arq. Salvador Reyes Ríos ) to their previous splendor – and splendid they were and splendid they are now. With no more than 28 rooms, the haciendas are Yucatán’s most luxurious lodgings. Personalized attention, a refined setting, lush gardens, tropical plants, antique furnishings and friendly staffs await you. You will feel totally pampered. Today, these restored haciendas make up The Luxury Collection –Haciendas Temozón,Santa Rosa, and San José, in Yucatán, and Uayamón and Puerta Campeche inCampeche. These hotel haciendas, Grand Tourism establishments that “don’t mean to spoil you, but they will”, are the ultimate getaway in total luxury. www.thehaciendas.com

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Built in 1870, this hacienda has been restored to its former elegance, and the lush gardens have been surrounded with 50 spacious guest rooms and suites, each one opening directly onto the gardens. Spa, pool, bar, and event facilities are lovely and inviting. The hacienda is a perfect setting for the culinary experience provided by the restaurant La Pitahaya. La Pitahaya is a bright, airy dining room with lovely doorways, skylights, and stained glass windows. The hacienda is located only 15 minutes from downtown Merida, off the road from Cancun to Merida, just west of the Periférico. www.haciendamisne.com.mx

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Once wingless and engrailed expression is established in adjacent cells, this pattern must be maintained to retain the parasegmental periodicity of the body plan established by the pair-rule genes. It should be remembered that the mRNAs and proteins involved in initiating these patterns are short-lived, and that the patterns must be maintained after their initiators are no longer being synthesized. The maintenance of these patterns is regulated by interactions between cells expressing wingless and those expressing engrailed. The Wingless protein, secreted from the wingless -expressing cells, diffuses to adjacent cells. The cells expressing engrailed can bind this protein because they contain the Drosophila membrane receptor protein for Wingless, D-Frizzled-2 (see Figure 6.23; Bhanot et al. 1996 ). This receptor activates the Wnt signal transduction pathway, resulting in the continued expression of engrailed ( Siegfried et al. 1994 ).

Moreover, this activation starts another portion of this reciprocal pathway. The Engrailed protein activates the transcription of the hedgehog gene in the engrailed -expressing cells. The Hedgehog protein can bind to the Hedgehog receptor (the Patched protein) on neighboring cells. When it binds to the adjacent posterior cells, it stimulates the expression of the wingless gene. The result is a reciprocal loop wherein the Engrailed-synthesizing cells secrete the Hedgehog protein, which maintains the expression of the wingless gene in the neighboring cells, while the Wingless-secreting cells maintain the expression of the engrailed and hedgehog genes in their neighbors in turn ( Heemskerk et al. 1991 ; Ingham et al. 1991 ; Mohler and Vani 1992 ). In this way, the transcription pattern of these two types of cells is stabilized. This interaction creates a stable boundary, as well as a signaling center from which Hedgehog and Wingless proteins diffuse across the parasegment.

The diffusion of these proteins is thought to provide the gradients by which the cells of the parasegment acquire their identities. This process can be seen in the dorsal epidermis, where the rows of larval cells produce different cuticular structures depending on their position within the segment. The 1° row consists of large, pigmented spikes called denticles. Posterior to these cells, the 2° row produces a smooth epidermal cuticle. The next two cell rows have a 3° fate, making small, thick hairs, and these are followed by several rows of cells that adopt the 4° fate, producing fine hairs ( Figure 9.26 ).

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